Antibodies

Phospho-BCR-Y177

Manufacturer Abclonal
Category Products / Antibody
Type Antibody Polyclonal
Specific against Human
Isotype IgG
Applications WB
Amount 50ug
Host Rabbit
ArtNr AP0606-50ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Available
Background
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
BCR
Gene Template
Human
GeneID
613
Route
Synthetic Peptide
SWISS
P11274
Protein MW (aa)
143kDa
Synonyms
ALL, CML, PHL, BCR1, D22S11, D22S662,
Purity
Affinity purification
Storage Buffer
Store at -20C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions
WB 1:500 - 1:2000
Illustration
Western blot analysis of extracts of K562 cells, using Phospho-BCR-Y177 antibody.
Amount: 50ug
Available: In stock
Listprice: €224.00
Price: €224.00
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Instruction sheet

AP0606-50ug.pdf