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AZD2281 (Olaparib)

AZD2281 (Olaparib)

Item no.	M1664-200mg
Manufacturer	AbMole
CASRN	763113-22-0
Amount	200mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	0,9986
Citations	Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. Bajrami, et al . EMBO Mol Med. 2012 Aug 30. PMID: 22933245 . Clinical trials and future potential of targeted therapy for ovarian cancer. Itamochi, et al . Int J Clin Oncol. 2012 Aug 28. PMID: 22926640 . PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition. Ibrahim, et al . Cancer Discov. 2012 Aug 24. PMID: 22915752 . Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Daemen, et al . Breast Cancer Res Treat. 2012 Sep,135(2):505-17. PMID: 22875744 . Olaparib , PARP1 inhibitor in ovarian cancer. Marchetti, et al . Expert Opin Investig Drugs. 2012 Jul 13. PMID: 22788971 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Olaparib; KU-0059436
Similar products	Olaparib, AZD2281, KU-0059436
Available
Target Information	PARP
Molecular Weight	434, 46
Solubility	DMSO 90 mg/mL; DMF 45 mg/mL
Bioactivity information	AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator.

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M1664-200mg-safety-datasheet.pdf