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Anti-SREBP2/SREBF2 Antibody Picoband®

Anti-SREBP2/SREBF2 Antibody Picoband®

Item no.	BOS-A01678-2-Dylight594
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Antibodies Obesity Flow Cytometry Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry Other Lipid\Cholesterol Metabolism Modulators
Type	Antibody
Format	Lyophilized
Applications	WB, FC, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	DyLight 594
Citations	1. Brown, M. S., Ye, J., Goldstein, J. L. HDL miR-ed down by SREBP introns. Science 328: 1495-1496, 2010. 2. DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L., Espenshade, P. J. Transport-dependent proteolysis of SREBP: relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99: 703-712, 1999. 3. Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., Hobbs, H. H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics 25: 667-673, 1995.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Gastrin/cholecystokinin type B receptor,CCK-B receptor,CCK-BR,Cholecystokinin-2 receptor,CCK2-R,CCKBR,CCKRB
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular weight	68 kDa
Calculated Molecular weight	50514 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Rat ELISA, 0.1-0.5 μg/ml
Gene Name	SREBF2
Gene Full Name	cholecystokinin B receptor
Background	Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants.
Immunogen	E.coli-derived human SREBP2/SREBF2 recombinant protein (Position: R371-L409).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Endocrine System, Metabolism, More Gpcr, Neuroscience, Neurotransmission, Obesity, Receptors / Channels
Protein Name	Carboxypeptidase M
Protein Function	Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Description	Boster Bio Anti-SREBP2/SREBF2 Antibody Picoband® catalog # A01678-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A01678-2-Dylight594-datasheet.pdf

BOS-A01678-2-Dylight594-safety-datasheet.pdf