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Anti-CSEN/KCNIP3 Antibody Picoband®

Anti-CSEN/KCNIP3 Antibody Picoband®

Item no.	BOS-PA2272-Dylight550
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Cell Biology Cell Status Western Blot Autophagy Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Testicular & Prostate Cancer Neuronal Cell Markers
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Dylight 550
Sensitivity	>5000 cells
Sequence	Belongs to the recoverin family.
Citations	1. Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR (March 1999). DREAM is a Ca2+-regulated transcriptional repressor.Nature 398 (6722): 80–4. 2. Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin 3. Savignac, M., Mellstrom, B., Bebin, A.-G., Oliveros, J. C., Delpy, L., Pinaud, E., Naranjo, J. R. Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. J. Immun. 185: 7527-7536, 2010.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Calsenilin,A-type potassium channel modulatory protein 3,DRE-antagonist modulator,DREAM,Kv channel-interacting protein 3,KChIP3,KCNIP3,CSEN,DREAM,KCHIP3
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Molecular Weight	29 kDa
Calculated Molecular weight	29231 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Human
Gene Name	KCNIP3
Gene Full Name	Calsenilin
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Adapters, Atherosclerosis, Cancer, Cardiovascular, Cell Type Markers, Cytoplasmic, Diabetes, Diabetes-associated, Growth Factors/Hormones, Heart Disease, Metabolism, Neurology Process, Neuroscience, Obesity, Signal Transduction, Tags & Cell Markers, Tumor Associated
Protein Name	Calsenilin
Protein Function	Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Subcellular Localization	Cytoplasm. Cell membrane ; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
Description	Boster Bio Anti-CSEN/KCNIP3 Antibody catalog # PA2272. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
Sequence Similarities	Belongs to the recoverin family.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA2272-Dylight550-datasheet.pdf

BOS-PA2272-Dylight550-safety-datasheet.pdf