MAP2K4 Antibody (OAEC04742)

Wet Ice

Ascitic fluid containing 0.03% sodium azide

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Purified recombinant fragment of human MAP2K4 expressed in E. Coli.