TNFR2 Antibody

Blue Ice

Observed: 64kDa

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

None

THP-1

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A synthetic peptide of human TNFRSF1B

tumor necrosis factor receptor superfamily, member 1B

Optimal dilutions for each application to be determined by the researcher.