HIF1α Rabbit mAb

Monoclonal Antibodies

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Recombinant protein of human HIF1α

93kDa

Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Invasion and Metastasis, Signal Transduction, mTOR Signaling Pathway, Cell Biology Developmental Biology, Autophagy, Endocrine Metabolism, Nucleotide metabolism, Warburg Effect, Cardiovascular, Angiogenesis, Hypoxia