Comparison

InVivoMab anti-mouse/human Integrin beta7 (Clone: FIB504)

Manufacturer Bio X Cell
Category
Type Antibody Monoclonal
Specific against Mouse
Clone FIB504
Isotype IgG2a
Applications in vivo
Amount 50mg
Host Rat
Item no. BE0062-50MG
eClass 6.1 32160702
eClass 9.0 42030590
Available
Quantity options
Description
The FIB504 monoclonal antibody reacts with human and mouse Integrin beta 7 which is a 130 kDa glycoprotein belonging to the Ig superfamily. Integrin beta7 associates with integrin alpha4 (CD49d) to form integrin alpha4beta7 also known as LPAM-1 as well as integrin alphaE (CD103) to form integrin alphaEbeta7. Integrin alpha4beta7 signals when bound to its ligands VCAM-1 (CD106), MAdCAM-1 and fibronectin, while integrin alphaEbeta7 binds to E-cadherin (CD324). Integrin alpha4beta7 is expressed by peripheral lymphocytes, small subsets of thymocytes, and bone marrow progenitors while integrin alphaEbeta7 is expressed on intestinal intraepithelial lymphocytes, T regulatory cells, and a subset of CD8+ T cells in the lamina propria and lymph nodes. Integrin beta7 plays roles in the adhesion of immune cells to endothelial cells thereby mediating cell migration and homing during an inflammatory response. The FIB504 antibody has been shown to have blocking activity.
Endotoxin
<2EU/mg (<0.002EU/ug)
Determined by LAL gel clotting assay
Formulation
PBS, pH 7.0
Contains no stabilizers or preservatives
Immunogen
TK1 cells
Isotype
Rat IgG2a, kappa
Molecular Weight
150 kDa
Production
Purified from tissue culture supernatant in an animal free facility
Purification
Protein G
Purity
>95%
Determined by SDS-PAGE
RRID
AB_1107715
Recommended InVivoPure Dilution Buffer
InVivoPure pH 7.0 Dilution Buffer(IP0070)
Recommended Isotype Control(s)
InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Reported Applications
Immunoprecipitation
Western blot
Flow cytometry
Sterility
0.2 uM filtered
Storage
The antibody solution should be stored at the stock concentration at 4C. Do not freeze.

Note: The presented information and documents (Manual, Product Datasheet and Safety Datasheet) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
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