PTEN (Ab-370) Antibody

Polyclonal Antibody

PTEN

10q23del antibody, BZS antibody, DEC antibody, GLM2 antibody, MGC11227 antibody, MHAM antibody, MMAC1 antibody, MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody, Mutated in multiple advanced cancers 1 antibody, Phosphatase and tensin homolog antibody, Phosphatase and tensin like protein antibody, Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN antibody, Pten antibody, PTEN_HUMAN antibody, PTEN1 antibody, TEP1 antibody

Peptide sequence around aa.368ca.372 (D-V-S-D-N) derived from Human PTEN.

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

Al-Khouri AM, et al. (2005). J Biol Chem. 280 (42):35195-35202.
Miller SJ, et al. (2002). FEBS Lett. 528 (1-3): 145-153.
Torres J, et al. (2001). J Biol Chem.276 (2): 993-998.
Vazquez F, et al. (2000). Mol Cell Biol.20 (14): 5010-5018.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Cell Biology

Peptide sequence around aa.368~372 (D-V-S-D-N) derived from Human PTEN.