Phospho-NTRK1 (Tyr791) Antibody

Polyclonal Antibody

NTRK1

gp140trk antibody, High affinity nerve growth factor receptor antibody, High affinity nerve growth factor receptor precursor antibody, MTC antibody, Neurotrophic tyrosine kinase receptor type 1 antibody, NTRK1 antibody, NTRK1_HUMAN antibody, Oncogene TRK antibody, p14-TrkA antibody, p140 TrkA antibody, p140-TrkA antibody, Slow nerve growth antibody, Trk A antibody, TRK antibody, Trk-A antibody, TRK1 antibody, TRK1-transforming tyrosine kinase protein antibody, Tropomyosin-related kinase A antibody, Tyrosine kinase receptor A antibody, Tyrosine kinase receptor antibody

Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Tina Garofalo, J. Biol. Chem., Dec 1998, 273: 35153.
Jan Grimm, J. Cell Biol., Jul 2001, 154: 345.
Jose L. Tomsig, J Androl, May 2006, 27: 348 - 357.
VI Shifrin and BG Neel J. Biol. Chem., Dec 1993, 268: 25376 - 25384

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Human

Polyclonal