Phospho-BRCA2 (Ser3291) Antibody

Polyclonal Antibody

BRCA2

BRCA 2 antibody, BRCA1/BRCA2 containing complex subunit 2 antibody, Brca2 antibody, BRCA2, DNA repair associated antibody, BRCA2_HUMAN antibody, BRCC 2 antibody, BRCC2 antibody, Breast and ovarian cancer susceptibility gene early onset antibody, breast and ovarian cancer susceptibility protein 2 antibody, Breast cancer 2 early onset antibody, Breast Cancer 2 tumor suppressor antibody, Breast cancer susceptibility protein BRCA2 antibody, Breast cancer type 2 susceptibility protein antibody, BROVCA2 antibody, FACD antibody, FAD 1 antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD 1 antibody, FANCD antibody, FANCD1 antibody, FANCD1 gene antibody, Fanconi anemia complementation group D1 antibody, Fanconi anemia group D1 protein antibody, GLM3 antibody, mutant BRCA2 antibody, OTTHUMP00000018803 antibody, OTTHUMP00000042401 antibody, PNCA2 antibody, XRCC11 antibody

Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2.

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.

Wooster R., Nature 378:789-792(1995).
Tavtigian S.V., Nat. Genet. 12:333-337(1996).
Dunham A., Nature 428:522-528(2004).

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Epigenetics and Nuclear Signaling

Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2.