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Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.Scherly D., Nature 363:182-185(1993).Shiomi T., Mutat. Res. 314:167-175(1994).Macinnes M.A., Mol. Cell. Biol. 13:6393-6402(1993).
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