Phospho-ATM (Ser1981) Antibody

Polyclonal Antibody

ATM

A-T mutated antibody, A-T mutated homolog antibody, AT mutated antibody, AT1 antibody, ATA antibody, Ataxia telangiectasia mutated antibody, Ataxia telangiectasia mutated gene antibody, Ataxia telangiectasia mutated homolog (human) antibody, Ataxia telangiectasia mutated homolog antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, ATM antibody, ATM serine/threonine kinase antibody, ATM_HUMAN antibody, DKFZp781A0353 antibody, MGC74674 antibody, OTTHUMP00000232981 antibody, Serine protein kinase ATM antibody, Serine-protein kinase ATM antibody, Serine/threonine-protein kinase ATM antibody, Tefu antibody, TEL1 antibody, TEL1, telomere maintenance 1, homolog antibody, TELO1 antibody, Telomere fusion protein antibody

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM.

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305.
Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252.
Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119.
Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.
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Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Epigenetics and Nuclear Signaling

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM.