ARID1B Antibody

Polyclonal Antibody

ARID1B

ARID1B antibody, BAF250B antibody, DAN15 antibody, KIAA1235 antibody, OSA2AT-rich interactive domain-containing protein 1B antibody, ARID domain-containing protein 1B antibody, BRG1-associated factor 250b antibody, BAF250B antibody, BRG1-binding protein hELD/OSA1 antibody, Osa homolog 2 antibody, hOsa2 antibody, p250R antibody

Synthesized peptide derived from interal of human BAF250B.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity. Binds DNA non-specifically.

Mungall A.J., Nature 425:805-811(2003).
Mangel L., J. Biol. Chem. 273:30466-30471(1998).
Imbert G., Nat. Genet. 14:285-291(1996).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from interal of Human BAF250B.