NTRK1 (Ab-791) Antibody

Polyclonal Antibody

NTRK1

gp140trk antibody, High affinity nerve growth factor receptor antibody, High affinity nerve growth factor receptor precursor antibody, MTC antibody, Neurotrophic tyrosine kinase receptor type 1 antibody, NTRK1 antibody, NTRK1_HUMAN antibody, Oncogene TRK antibody, p14-TrkA antibody, p140 TrkA antibody, p140-TrkA antibody, Slow nerve growth antibody, Trk A antibody, TRK antibody, Trk-A antibody, TRK1 antibody, TRK1-transforming tyrosine kinase protein antibody, Tropomyosin-related kinase A antibody, Tyrosine kinase receptor A antibody, Tyrosine kinase receptor antibody

Peptide sequence around aa.789ca.793 (P-V-Y-L-D) derived from Human TrkA.

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23, 104(43):17210-5.
Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24, 104(30):12270-5
Inoue K, et al. J Biol Chem. 2007 Aug 17, 282(33):24175-84

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Human

Polyclonal