ZFYVE19 Antibody

Polyclonal Antibody

ZFYVE19

Abscission/NoCut checkpoint regulator antibody, ANCHR antibody, MLL partner containing FYVE domain antibody, MPFYVE antibody, ZFY19_HUMAN antibody, ZFYVE 19 antibody, Zfyve19 antibody, Zinc finger FYVE domain containing protein 19 antibody, Zinc finger FYVE domain-containing protein 19 antibody, Zinc finger FYVE type containing 19 antibody, Zinc finger, FYVE domain containing 19 antibody

Synthesized peptide derived from internal of human ZFYVE19.

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Chinwalla V., Oncogene 22:1400-1410(2003).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human ZFYVE19.