IGF1R (Ab-1280) Antibody

Polyclonal Antibody

IGF1R

CD221 antibody, CD221 antigen antibody, IGF 1 receptor antibody, IGF 1R antibody, IGF I receptor antibody, IGF-I receptor antibody, Igf1r antibody, IGF1R_HUMAN antibody, IGFIR antibody, IGFIRC antibody, IGFR antibody, Insulin like growth factor 1 receptor antibody, Insulin like growth factor 1 receptor precursor antibody, Insulin-like growth factor 1 receptor beta chain antibody, Insulin-like growth factor I receptor antibody, JTK13 antibody, MGC142170 antibody, MGC142172 antibody, MGC18216 antibody, Soluble IGF1R variant 1 antibody, Soluble IGF1R variant 2 antibody

Peptide sequence around aa. 1278ca.1282 (S-F-Y-Y-S ) derived from Human IGF-1R .

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
Baserga, R. et al. (2000) Oncogene 19, 5574-5581
Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
O'Connor R, et al. Mol Cell Biol 1997 Jan, 17(1): 427-35

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Signal Transduction

Peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .