HSP90AB1 (Ab-254) Antibody

Polyclonal Antibody

HSP90AB1

90 kda heat shock protein beta HSP90 beta antibody, D6S182 antibody, FLJ26984 antibody, Heat shock 84 kDa antibody, Heat shock 90kD protein 1, beta antibody, Heat shock 90kDa protein 1 beta antibody, Heat shock protein 90 alpha family class B member 1 antibody, Heat shock protein 90 kDa antibody, Heat shock protein 90kDa alpha (cytosolic) class B member 1 antibody, Heat shock protein 90kDa alpha family class B member 1 antibody, Heat shock protein beta antibody, Heat shock protein HSP 90 beta antibody, Heat shock protein HSP 90-beta antibody, HS90B_HUMAN antibody, HSP 84 antibody, HSP 90 antibody, HSP 90 b antibody, HSP 90b antibody, HSP84 antibody, HSP90 BETA antibody, hsp90ab1 antibody, HSP90B antibody, HSPC2 antibody, HSPCB antibody

Synthesized non-phosphopeptide derived from human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E).

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Lothar Goretzki, AACR Meeting Abstracts, Apr 2006, 2006: 468.
Jean-Fran ois Louvion, Mol. Biol. Cell, Nov 1998, 9: 3071.
Angelika Lueking, Mol. Cell. Proteomics, Dec 2003, 2: 1342.
Jason Fontana Circ, Res., May 2002, 90: 866.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized non-phosphopeptide derived from Human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E).