SMARCC2 Antibody

Polyclonal Antibody

SMARCC2

BAF 170 antibody, BAF170 antibody, BRG1 associated factor 170 antibody, BRG1-associated factor 170 antibody, Chromatin remodeling complex BAF170 subunit antibody, CRACC 2 antibody, CRACC2 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody, Rsc 8 antibody, Rsc8 antibody, SMARCC 2 antibody, Smarcc2 antibody, SMRC2_HUMAN antibody, SWI/SNF complex 170 kDa subunit antibody, SWI/SNF complex subunit SMARCC2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody, SWI3 like protein antibody

Synthesized peptide derived from internal of human SMRC2.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity.

Wang W., Genes Dev. 10:2117-2130(1996).
Kim J.-E., J. Proteome Res. 4:1339-1346(2005).
Olsen J.V., Cell 127:635-648(2006).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from internal of Human SMRC2.