RAD50 Antibody

Polyclonal Antibody

RAD50

DNA repair protein RAD50 antibody, hRAD50 antibody, hsRAD50 antibody, Mrell antibody, NBSLD antibody, Rad 50 antibody, RAD50 2 antibody, rad50 antibody, RAD50 homolog (S cerevisiae) antibody, RAD50 homolog antibody, RAD50 PEN antibody, RAD50, S. cerevisiae, homolog of antibody, RAD50_HUMAN antibody, RAD502 antibody, Rad50l antibody, Truncated RAD50 protein antibody

Synthesized peptide derived from internal of human RAD50.

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).
Kim K.K., Gene 235:59-67(1999).
Carney J.P., Cell 93:477-486(1998).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from internal of Human RAD50.