DR6 Antibody

Blue Ice

68 kDa

DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κ B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

Trial Size

3549262

PRS-1201-0.1mg

1 mg/ml

DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6.

The immunogen is located within amino acids 30 - 80 of DR6.

tumor necrosis factor receptor superfamily, member 21

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.