Comparison

Recombinant Human Interleukin-1 beta (IL1B) (Active)

Manufacturer Biomatik
Category
Type Proteins Recombinant
Specific against Human
Amount 1mg
Item no. BM-RPC26868-1mg
eClass 6.1 34160400
eClass 9.0 42020190
Available
Gene Name
IL1B
Alternative Names
Interleukin-1 beta, Catabolin, IL1F2, IL1B.
Uniprot
P01584
Source
E.coli
Expression Region
117-269aa
AA Sequence
APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQD MEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS CVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIE INNKLEFESAQFPNWYISTSQAENMPVFLGGTKGG QDITDFTMQFVSS
Sequence Info
Full Length of Mature Protein
Tag Info
Tag-Free
Theoretical MW
17.5 kDa
Purity
>95% as determined by SDS-PAGE.
Storage Buffer
Lyophilized from a 0.2 um filtered 20 mM PB, 150 mM NaCl, pH 7.4
Endotoxin Level
Less than 1.0 EU/ug as determined by LAL method.
Biological Activity
The ED50 as determined by its ability to induce NFKB reporter gene expression in HEK 293 cell line is typically 142 pg/mL
Shipping Condition
Ice packs
Storage
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date
1 year
Restriction
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance
IL1B belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Function
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Subcellular location
Cytoplasm, cytosol, Lysosome, Secreted, exosome, Secreted
Protein Families
IL-1 family
Tissue Specificity
Expressed in activated monocytes/macrophages (at protein level).
Paythway
MAPKsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet and Safety Datasheet) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 1mg
Available: In stock
available
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