Comparison

Recombinant Human Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Active)

Manufacturer Biomatik
Category
Type Proteins Recombinant
Specific against Human
Amount 50ug
Item no. BM-RPC27020-50ug
eClass 6.1 34160400
eClass 9.0 42020190
Available
Gene Name
PCSK9
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1
Uniprot
Q8NBP7
Source
Mammalian cell
Expression Region
31-152aa & 153-692aa (V474I, G670E)
AA Sequence
QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFH RCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELAL KLPHVDYIEEDSSVFAQ & SIPWNLERITPPRYR ADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMV TDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGR DAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIR KSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARA GVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQ DQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCST CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELR QRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPS THGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEE LLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGG EGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHC HQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQ CVGHREASIHASCCHAPGLECKVKEHGIPAPQEQV TVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVR SRDVSTTGSTSEEAVTAVAICCRSRHLAQASQELQ
Sequence Info
Full Length of Mature Protein
Tag Info
C-terminal Avi-tagged
Theoretical MW
14 & 59 kDa
Purity
>95% as determined by SDS-PAGE.
Storage Buffer
0.2 um filtered 50 mM HEPES, 150 mM NaCl, 20% Glycerol, pH 7.4
Endotoxin Level
Less than 1.0 EU/ug as determined by LAL method.
Biological Activity
The ED50 as determined by its ability to bind Human LDLR in functional ELISA is less than 200 ug/ml
Shipping Condition
Ice packs
Storage
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date
1 year
Restriction
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
Function
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members
Involvement in disease
Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3)
Subcellular location
Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus
Protein Families
Peptidase S8 family
Tissue Specificity
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Paythway
Cholesterolmetabolism

Note: The presented information and documents (Manual, Product Datasheet and Safety Datasheet) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50ug
Available: In stock
available
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