Anti-PTEN (D375) Antibody

Primary Antibodies

47166 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Tumor suppressor. Acts as a dual-specificity protein
phosphatase, dephosphorylating tyrosine-, serine- and threonine-
phosphorylated proteins. Also acts as a lipid phosphatase,
removing the phosphate in the D3 position of the inositol ring
from phosphatidylinositol 3, 4, 5-trisphosphate,
phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-
phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of
substrate preference in vitro PtdIns (3, 4, 5)P3 > PtdIns (3, 4)P2 >
PtdIns3P > Ins (1, 3, 4, 5)P4 (PubMed:26504226). The lipid phosphatase
activity is critical for its tumor suppressor function.
Antagonizes the PI3K-AKT/PKB signaling pathway by
dephosphorylating phosphoinositides and thereby modulating cell
cycle progression and cell survival. The unphosphorylated form
cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates
tyrosine-phosphorylated focal adhesion kinase and inhibits cell
migration and integrin-mediated cell spreading and focal adhesion
formation. Plays a role as a key modulator of the AKT-mTOR
signaling pathway controlling the tempo of the process of newborn
neurons integration during adult neurogenesis, including correct
neuron positioning, dendritic development and synapse formation.
May be a negative regulator of insulin signaling and glucose
metabolism in adipose tissue. The nuclear monoubiquitinated form
possesses greater apoptotic potential, whereas the cytoplasmic
nonubiquitinated form induces less tumor suppressive ability. In
motile cells, suppresses the formation of lateral pseudopods and
thereby promotes cell polarization and directed movement.

Boster Bio Anti-PTEN (D375) Antibody catalog # A00006-2. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.