Anti-HP Antibody (Center)

Item no.	BOS-A00062-3-400ul
Manufacturer	Boster
Amount	400 ul
Quantity options	400 ul 80 ul
Category	Metabolism Diabetes Glucose Homeostasis Obesity Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence
Applications	WB, FC, IF, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Alias	Haptoglobin,Zonulin,Haptoglobin alpha chain,Haptoglobin beta chain,HP
Available
Manufacturer - Applications	IHC-P-Leica, WB, IF, Flow Cytometry
Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	45205 Da
Clonality	Polyclonal
Application Details	IF: 1:10-1:50 WB: 1:1000-1:2000 IHC-P-Leica: 1:500 FC: 1:10-1:50
Gene Name	HP
Background	This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen	This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.
Contents	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Manufacturer - Research Category	Cardiovascular, Cell Biology, Signal Transduction, Immunology
Protein Function	As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Subcellular Localization	Secreted.
Description	Boster Bio Anti-HP Antibody (Center) (Catalog # A00062-3). Tested in IHC-P-Leica, WB, IF, Flow Cytometry application(s). This antibody reacts with Human, Mouse.
Tissue Specificity	Expressed by the liver and secreted in plasma.

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BOS-A00062-3-400ul-datasheet.pdf

BOS-A00062-3-400ul-safety-datasheet.pdf