Anti-IGF-1R (phospho-Y980) Antibody

Primary Antibodies

154793 MW

IHC: 1:50-1:200

Insulin-like growth factor 1 receptor

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Receptor tyrosine kinase which mediates actions of
insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity
and IGF2 and insulin (INS) with a lower affinity. The activated
IGF1R is involved in cell growth and survival control. IGF1R is
crucial for tumor transformation and survival of malignant cell.
Ligand binding activates the receptor kinase, leading to receptor
autophosphorylation, and tyrosines phosphorylation of multiple
substrates, that function as signaling adapter proteins including,
the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
Phosphorylation of IRSs proteins lead to the activation of two
main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK
pathway. The result of activating the MAPK pathway is increased
cellular proliferation, whereas activating the PI3K pathway
inhibits apoptosis and stimulates protein synthesis.
Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of
PI3K (PIK3R1), leading to activation of several downstream
substrates, including protein AKT/PKB. AKT phosphorylation, in
turn, enhances protein synthesis through mTOR activation and
triggers the antiapoptotic effects of IGFIR through
phosphorylation and inactivation of BAD. In parallel to PI3K-
driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1
or Shc leads to recruitment of Ras and activation of the ras-MAPK
pathway. In addition to these two main signaling pathways IGF1R
signals also through the Janus kinase/signal transducer and
activator of transcription pathway (JAK/STAT). Phosphorylation of
JAK proteins can lead to phosphorylation/activation of signal
transducers and activators of transcription (STAT) proteins. In
particular activation of STAT3, may be essential for the
transforming activity of IGF1R. The JAK/STAT pathway activates
gene transcription and may be responsible for the transforming
activity. JNK kinases can also be activated by the IGF1R. IGF1
exerts inhibiting activities on JNK activation via phosphorylation
and inhibition of MAP3K5/ASK1, which is able to directly associate
with the IGF1R.

Boster Bio Anti-IGF-1R (phospho-Y980) Antibody catalog # A00070Y980. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.