Anti-Phospho-Sp1 (T453) Antibody

Primary Antibodies

80693 MW

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000

Transcription factor Sp1

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Transcription factor that can activate or repress
transcription in response to physiological and pathological
stimuli. Binds with high affinity to GC-rich motifs and regulates
the expression of a large number of genes involved in a variety of
processes such as cell growth, apoptosis, differentiation and
immune responses. Highly regulated by post-translational
modifications (phosphorylations, sumoylation, proteolytic
cleavage, glycosylation and acetylation). Binds also the PDGFR-
alpha G-box promoter. May have a role in modulating the cellular
response to DNA damage. Implicated in chromatin remodeling. Plays
an essential role in the regulation of FE65 gene expression. In
complex with ATF7IP, maintains telomerase activity in cancer cells
by inducing TERT and TERC gene expression. Isoform 3 is a stronger
activator of transcription than isoform 1. Positively regulates
the transcription of the core clock component ARNTL/BMAL1
(PubMed:10391891, PubMed:11371615, PubMed:11904305,
PubMed:14593115, PubMed:16377629, PubMed:16478997,
PubMed:16943418, PubMed:17049555, PubMed:18171990,
PubMed:18199680, PubMed:18239466, PubMed:18513490,
PubMed:18619531, PubMed:19193796, PubMed:20091743,
PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1
on the c-FOS promoter. Plays a role in protecting cells against
oxidative stress following brain injury by regulating the
expression of RNF112 (By similarity).

Boster Bio Anti-Phospho-Sp1 (T453) Antibody catalog # A00110T453-1. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-Phospho-Sp1 (T453) Antibody catalog # A00110T453-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.