Anti-SOCS-3 Antibody

Primary Antibodies

24770 MW

WB: 1:500-1:1000

Suppressor of cytokine signaling 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

SOCS family proteins form part of a classical negative
feedback system that regulates cytokine signal transduction. SOCS3
is involved in negative regulation of cytokines that signal
through the JAK/STAT pathway. Inhibits cytokine signal
transduction by binding to tyrosine kinase receptors including
gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin
receptors. Binding to JAK2 inhibits its kinase activity.
Suppresses fetal liver erythropoiesis. Regulates onset and
maintenance of allergic responses mediated by T-helper type 2
cells. Regulates IL-6 signaling in vivo (By similarity). Probable
substrate recognition component of a SCF-like ECS (Elongin BC-
CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation
of target proteins. Seems to recognize IL6ST (By similarity).

Widely expressed with high expression in
heart, placenta, skeletal muscle, peripheral blood leukocytes,
fetal and adult lung, and fetal liver and kidney. Lower levels in
thymus.