Anti-PPAR Gamma (phospho-S112) PPARG Antibody

Item no.	BOS-A00449S112
Manufacturer	Boster
Amount	100 ul
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism By Cell Type Carcinoma Immunohistochemistry Western Blot Other Lipid\Cholesterol Metabolism Modulators
Format	Liquid
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	Peroxisome proliferator-activated receptor gamma,PPAR-gamma,Nuclear receptor subfamily 1 group C member 3,PPARG,NR1C3
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	57620 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:1000 IHC: 1:50-1:200
Gene Name	PPARG
Gene Full Name	Peroxisome proliferator-activated receptor gamma
Immunogen	Synthetic phosphopeptide derived from human PPARγ around the phosphorylation site of Serine 112.
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	Peroxisome proliferator-activated receptor gamma
Protein Function	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Subcellular Localization	Nucleus. Cytoplasm. Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
Description	Boster Bio Anti-PPAR Gamma (phospho-S112) PPARG Antibody catalog # A00449S112. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.

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BOS-A00449S112-datasheet.pdf

BOS-A00449S112-safety-datasheet.pdf