Anti-TRPV4 Antibody

Primary Antibodies

98281 MW

WB 1:500-1:2000
ELISA 1:20000

Transient receptor potential cation channel subfamily V member 4

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Non-selective calcium permeant cation channel involved
in osmotic sensitivity and mechanosensitivity. Activation by
exposure to hypotonicity within the physiological range exhibits
an outward rectification (PubMed:18826956, PubMed:18695040). Also
activated by heat, low pH, citrate and phorbol esters
(PubMed:16293632, PubMed:18826956, PubMed:18695040,
PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of
intracellular Ca (2+) potentiates currents. Channel activity seems
to be regulated by a calmodulin-dependent mechanism with a
negative feedback mechanism (PubMed:12724311, PubMed:18826956).
Promotes cell-cell junction formation in skin keratinocytes and
plays an important role in the formation and/or maintenance of
functional intercellular barriers (By similarity). Acts as a
regulator of intracellular Ca (2+) in synoviocytes
(PubMed:19759329). Plays an obligatory role as a molecular
component in the nonselective cation channel activation induced by
4-alpha-phorbol 12, 13-didecanoate and hypotonic stimulation in
synoviocytes and also regulates production of IL-8
(PubMed:19759329). Together with PKD2, forms mechano- and
thermosensitive channels in cilium (PubMed:18695040). Negatively
regulates expression of PPARGC1A, UCP1, oxidative metabolism and
respiration in adipocytes (By similarity). Regulates expression of
chemokines and cytokines related to proinflammatory pathway in
adipocytes (By similarity). Together with AQP5, controls
regulatory volume decrease in salivary epithelial cells (By
similarity). Required for normal development and maintenance of
bone and cartilage (PubMed:26249260).

Boster Bio Anti-TRPV4 Antibody catalog # A00565-1. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-TRPV4 Antibody catalog # A00565-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.