Anti-TRPV4 Antibody

TRPV4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Polyclonal

TRPV4

TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.

TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.

TRPV4 antibody is affinity chromatography purified via peptide column.

Signal Transduction

Non-selective calcium permeant cation channel involved
in osmotic sensitivity and mechanosensitivity. Activation by
exposure to hypotonicity within the physiological range exhibits
an outward rectification (PubMed:18826956, PubMed:18695040). Also
activated by heat, low pH, citrate and phorbol esters
(PubMed:16293632, PubMed:18826956, PubMed:18695040,
PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of
intracellular Ca (2+) potentiates currents. Channel activity seems
to be regulated by a calmodulin-dependent mechanism with a
negative feedback mechanism (PubMed:12724311, PubMed:18826956).
Promotes cell-cell junction formation in skin keratinocytes and
plays an important role in the formation and/or maintenance of
functional intercellular barriers (By similarity). Acts as a
regulator of intracellular Ca (2+) in synoviocytes
(PubMed:19759329). Plays an obligatory role as a molecular
component in the nonselective cation channel activation induced by
4-alpha-phorbol 12, 13-didecanoate and hypotonic stimulation in
synoviocytes and also regulates production of IL-8
(PubMed:19759329). Together with PKD2, forms mechano- and
thermosensitive channels in cilium (PubMed:18695040). Negatively
regulates expression of PPARGC1A, UCP1, oxidative metabolism and
respiration in adipocytes (By similarity). Regulates expression of
chemokines and cytokines related to proinflammatory pathway in
adipocytes (By similarity). Together with AQP5, controls
regulatory volume decrease in salivary epithelial cells (By
similarity). Required for normal development and maintenance of
bone and cartilage (PubMed:26249260).

Boster Bio Anti-TRPV4 Antibody (Catalog # A00565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-TRPV4 Antibody (Catalog # A00565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.