Anti-Dipeptidyl peptidase 4 DPP4 Antibody

Primary Antibodies

88279 MW

WB: 1:500-1:1000

Dipeptidyl peptidase 4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Cell surface glycoprotein receptor involved in the
costimulatory signal essential for T-cell receptor (TCR)-mediated
T-cell activation. Acts as a positive regulator of T-cell
coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its
binding to CAV1 and CARD11 induces T-cell proliferation and NF-
kappa-B activation in a T-cell receptor/CD3-dependent manner. Its
interaction with ADA also regulates lymphocyte-epithelial cell
adhesion. In association with FAP is involved in the pericellular
proteolysis of the extracellular matrix (ECM), the migration and
invasion of endothelial cells into the ECM. May be involved in the
promotion of lymphatic endothelial cells adhesion, migration and
tube formation. When overexpressed, enhanced cell proliferation, a
process inhibited by GPC3. Acts also as a serine exopeptidase with
a dipeptidyl peptidase activity that regulates various
physiological processes by cleaving peptides in the circulation,
including many chemokines, mitogenic growth factors, neuropeptides
and peptide hormones. Removes N-terminal dipeptides sequentially
from polypeptides having unsubstituted N-termini provided that the
penultimate residue is proline.

Boster Bio Anti-Dipeptidyl peptidase 4 DPP4 Antibody catalog # A00597. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.