Anti-Cysteine protease ATG4A ATG4A Antibody

Primary Antibodies

45378 MW

ATG4A antibody can be used for detection of ATG4A by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Autophagy related 4A, cysteine peptidase

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1, 2). ATG4A, also known as AUTL2, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4).

ATG4A antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Autophagy related 4A, cysteine peptidase

Cytoplasm.

Widely expressed, at a low level, and the
highest expression is observed in skeletal muscle and brain. Also
detected in fetal liver.

ATG4A antibody is human, mouse and rat reactive. At least two isoforms of ATG4A are known to exist; this antibody will detect both isoforms. ATG4A is predicted to not cross-react with other ATG4 proteins.