Anti-PDX1/Ipf1 Rabbit Monoclonal Antibody

Primary Antibodies, Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

30771 MW

WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200

Pancreas/duodenum homeobox protein 1

Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Atherosclerosis, Cancer, Cardiovascular, Developmental Biology, Diabetes, Diabetes-associated, Epigenetics and Nuclear Signaling, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Metabolism, Organogenesis, Signal Transduction, Stem Cells, Transcription

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Boster Bio Anti-PDX1/Ipf1 Rabbit Monoclonal Antibody catalog # M00491. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.