Anti-PKM2 Rabbit Monoclonal Antibody

Primary Antibodies, Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

57937 MW

WB 1:1000-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
FC 1:50

Pyruvate kinase PKM

Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Cell Cycle, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Boster Bio Anti-PKM2 Rabbit Monoclonal Antibody catalog # M01173. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.