Comparison

Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody

Manufacturer Boster
Category
Type Antibody Polyclonal
Specific against Human
Isotype IgG
Format Lyophilized
Applications WB
Amount 100 ug/vial
Host Rabbit
Item no. BOS-PA1611
Targets IDO1
eClass 6.1 32160702
eClass 9.0 32160702
Available
Manufacturers Product Category
Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category
Amino Acid Metabolism, Amino Acids, Atherosclerosis, Cancer, Cardiovascular, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Vascular Inflammation
Short Description
Boster Bio Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody catalog # PA1611. Tested in WB applications. This antibody reacts with Human.
Description
Boster Bio Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody catalog # PA1611. Tested in WB applications. This antibody reacts with Human.
Background
IDO1 (INDOLEAMINE 2, 3-DIOXYGENASE), INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. INDO Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2, 3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
Gene Name
IDO1
Application Details
Western blot, 0.1-0.5μg/ml, Human
Application Notes
Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality
Polyclonal
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human IDO1.
Purification
Immunogen affinity purified.
Cross-reactivity
No cross-reactivity with other proteins
Storage
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name
Indoleamine 2, 3-dioxygenase 1
Molecular Weight
45326 MW
Protein Function
Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen..
Protein Name
Indoleamine 2, 3-dioxygenase 1(IDO-1)
Sequence Similarities
Belongs to the indoleamine 2, 3-dioxygenase family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug/vial
Available: In stock
available

Delivery expected until 5/2/2024 

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