Manufacturer |
Boster
|
Category |
|
Type |
Elisa-Kit |
Specific against |
Human |
Applications |
ELISA |
Amount |
96 wells/kit, with removable strips. |
Item no. |
BOS-EK0963 |
Targets |
HLA-C |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Available |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Adaptive Immunity, Class I, Immunology |
Short Description |
Human MICB ELISA Kit PicoKine® (96 Tests). Quantitate Human MICB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. |
Description |
Human MICB ELISA Kit PicoKine® (96 Tests). Quantitate Human MICB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. |
Background |
MHC class I polypeptide-related sequence B, also called MICB is a protein that in humans is encoded by the MICB gene. The MICB gene is mapped to 6p21.33. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation. This gene acts as a stress-induced self-antigen that is recognized by gamma delta T cells. It is the ligand for the KLRK1/NKG2D receptor and binds to KLRK1 leads to cell lysis. |
Gene Name |
MICB |
Immunogen |
Expression system for standard: NS0; Immunogen sequence: A23-G298 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). |
Capture antibody|Detection antibody |
monoclonal antibody from mouse|polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin or EDTA |
Gene Full Name |
MHC class I polypeptide-related sequence B |
Molecular Weight |
42646 MW |
Protein Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.. |
Subcellular Localization |
Cell membrane ; Single-pass type I membrane protein. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.. |
Tissue Specificity |
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.. |
Protein Name |
MHC class I polypeptide-related sequence B |
Sequence Similarities |
Belongs to the MHC class I family. MIC subfamily. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.