Recombinant Human Oxidized low-density lipoprotein receptor 1(OLR1),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Amount 10ug
Host E.coli
ArtNr CSB-EP016331HU-10
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research Topic
Cardiovascular
Uniprot ID
P78380
Gene Names
OLR1
Organism
Homo sapiens (Human)
AA Sequence
MQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAE EASQESENELKEMIETLARKLNEKSKEQMELHHQN LNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGS FNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISY SSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRG AVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKK ANLRAQ
Expression Region
58-273aa
Sequence Info
Extracellular Domain
Tag Info
N-terminal 6xHis-tagged
MW
28.7 kDa
Alternative Name(s)
C-type lectin domain family 8 member ALectin-like oxidized LDL receptor 1 ; LOX-1 ; Lectin-like oxLDL receptor 1 ; hLOX-1Lectin-type oxidized LDL receptor 1
Relevance
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Reference
Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to oxLDL.Ohki I., Ishigaki T., Oyama T., Matsunaga S., Xie Q., Ohnishi-Kameyama M., Murata T., Tsuchiya D., Machida S., Morikawa K., Tate S.Structure 13:905-917(2005)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 10ug
Available: In stock
Listprice: €140.00
Price: €140.00
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