Comparison

Recombinant Human Hydroxymethylglutaryl-CoA lyase, mitochondrial(HMGCL)

Manufacturer Cusabio
Category
Type Proteins
Specific against other
Amount 10ug
Host E.coli
Item no. CSB-EP010563HU-10
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Alternative Name(s)
3-hydroxy-3-methylglutarate-CoA lyase
AA Sequence
TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDM LSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQK FPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASE LFTKKNINCSIEESFQRFDAILKAAQSANISVRGY VSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISL GDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDT YGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGA SGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFIC QALNRKTSSKVAQATCKL
Research Topic
Signal Transduction
Uniprot ID
P35914
Gene Names
HMGCL
Tag Info
N-terminal GST-tagged
Expression Region
1-325aa
MW of Fusion Proten
58, 5
Sequence Info
Full Length
Relevance
Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
Reference
"3-hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency."
Mitchell G.A., Robert M.-F., Hruz P.W., Wang S., Fontaine G., Behnke C.E., Mende-Mueller L.M., Schappert K., Lee C., Gibson K.M., Miziorko H.M.
J. Biol. Chem. 268:4376-4381(1993)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Species
Homo sapiens (Human)
Amount: 10ug
Available: In stock
Listprice: €154.00
Price: €154.00
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