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Recombinant Human Heat shock protein HSP 90-beta(HSP90AB1)

Recombinant Human Heat shock protein HSP 90-beta(HSP90AB1)

Manufacturer	Cusabio
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	10ug
Host	E.coli
Item no.	CSB-EP010808HU-10
Conjugate/Tag	Myc
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research Topic	Signal Transduction
Uniprot ID	P08238
Gene Names	HSP90AB1
Organism	Homo sapiens (Human)
AA Sequence	PEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNK EIFLRELISNASDALDKIRYESLTDPSKLDSGKEL KIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIA KSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAE KVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIG RGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGY PITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEE KPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEE LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHL AVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKN NIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDL PLNISREMLQQSKILKVIRKNIVKKCLELFSELAE DKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLR YHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESK EQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLK EFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFE NLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTY GWTANMERIMKAQALRDNSTMGYMMAKKHLEINPD HPIVETLRQKAEADKNDKAVKDLVVLLFETALLSS GFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPN AAVPDEIPPLEGDEDASRMEEVD
Expression Region	2-724aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
MW	88.1 kDa
Alternative Name(s)	Heat shock 84KDA
Relevance	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Reference	"Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens." Hoffmann T., Hovemann B. Gene 74:491-501(1988)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function
Subcellular Location	Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane
Protein Families	Heat shock protein 90 family
Paythway	Estrogensignalingpathway
Tag Information	N-terminal 10xHis-tagged and C-terminal Myc-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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