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Recombinant Human Modulator of apoptosis 1(MOAP1)

Recombinant Human Modulator of apoptosis 1(MOAP1)

Manufacturer	Cusabio
Category	Oncology Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	50ug
Host	E.coli
Item no.	CSB-EP014693HU-50
Conjugate/Tag	GST
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research Topic	Cell Biology
Uniprot ID	Q96BY2
Gene Names	MOAP1
Organism	Homo sapiens (Human)
AA Sequence	MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEI EEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLT AETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSR LNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPE MWAPMLAQALEALQPALQCLKYKKLRVFSGRESPE PGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESL RGPALDVIRVLKINNPLITVDECLQALEEVFGVTD NPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLV QRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPE DGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNF
Expression Region	1-351aa
Sequence Info	Full Length
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	66.5 kDa
Alternative Name(s)	Paraneoplastic antigen Ma4
Relevance	Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Reference	"MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains." Tan K.O., Tan K.M.L., Chan S.-L., Yee K.S.Y., Bevort M., Ang K.C., Yu V.C. J. Biol. Chem. 276:2802-2807(2001)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Protein Families	PNMA family
Tissue Specificity	Widely expressed, with high levels in heart and brain.
Tag Information	N-terminal GST-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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