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Recombinant Human Molybdopterin synthase catalytic subunit(MOCS2)

Manufacturer Cusabio
Category
Type Proteins
Specific against other
Amount 50ug
Host E.coli
Item no. CSB-EP014706HU-50
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research Topic
Signal Transduction
Uniprot ID
O96007
Gene Names
MOCS2
Organism
Homo sapiens (Human)
AA Sequence
MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKD MDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGA ISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRK ICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVS SAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESST WKGNKECFWASNS
Expression Region
1-188aa
Sequence Info
Full Length
Source
E.coli
Tag Info
N-terminal GST-tagged
MW
47.9 kDa
Alternative Name
MOCO1-B
Molybdenum cofactor synthesis protein 2 large subunit
Molybdenum cofactor synthesis protein 2B
Relevance
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Reference
"Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames."
Stallmeyer B., Drugeon G., Reiss J., Haenni A.L., Mendel R.R.
Am. J. Hum. Genet. 64:698-705(1999)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Involvement in disease
Molybdenum cofactor deficiency, complementation group B (MOCODB)
Subcellular Location
Cytoplasm, cytosol
Protein Families
MoaE family, MOCS2B subfamily
Tissue Specificity
Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes.
Amount: 50ug
Available: In stock
Listprice: €227.63
Price: €227.63
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