Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
100ug |
Host |
E.coli |
Item no. |
CSB-EP016078HU-100 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Areas |
Neuroscience |
Uniprot ID |
O14511 |
Gene Names |
NRG2 |
Organism |
Homo sapiens (Human) |
AA Sequence |
CYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSS NSTREPPASGRVALVKVLDKWPLRSGGLQREQVIS VGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDT NGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGE KQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIK YGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT VRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNG GVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYM PDPKQKAEELYQKR |
Expression Region |
112-405aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
48.8 kDa |
Alternative Name(s) |
Divergent of neuregulin-1 ; DON-1Neural- and thymus-derived activator for ERBB kinases ; NTAK |
Relevance |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
Reference |
Ligand discrimination in signaling through an ErbB4 receptor homodimer.Sweeney C., Lai C., Riese D.J. II, Diamonti A.J., Cantley L.C., Carraway K.L. IIIJ. Biol. Chem. 275:19803-19807(2000) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Form |
Liquid or Lyophilized powder |
Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
Subcellular Location |
Pro-neuregulin-2, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein |
Protein Families |
Neuregulin family |
Tissue Specificity |
Restricted to the cerebellum in the adult. |
Paythway |
ErbBsignalingpathway |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.