Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
500ug |
Host |
E.coli |
Item no. |
CSB-EP016079HU-500 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Cancer |
Uniprot ID |
P56975 |
Gene Names |
NRG3 |
Organism |
Homo sapiens (Human) |
AA Sequence |
MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAG GGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVV PLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDS KGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATP SAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPI RASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRP PVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLS PFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYS TERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHK HCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEF MESEEVYQRQ |
Expression Region |
1-360aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
53.8 kDa |
Alternative Name(s) |
Pro-NRG3 |
Relevance |
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes |
Reference |
"Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4."Zhang D., Sliwkowski M.X., Mark M., Frantz G., Akita R., Sun Y., Hillan K., Crowley C., Brush J., Godowski P.J.Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
Subcellular Location |
Pro-neuregulin-3, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein, Note=Does not seem to be active, SUBCELLULAR LOCATION: Neuregulin-3: Secreted, SUBCELLULAR LOCATION: Isoform 3: Cell membrane, Single-pass type I membrane protein |
Protein Families |
Neuregulin family |
Tissue Specificity |
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. |
Paythway |
ErbBsignalingpathway |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.