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Recombinant Rat Neuroendocrine convertase 2(Pcsk2)

Recombinant Rat Neuroendocrine convertase 2(Pcsk2)

Manufacturer	Cusabio
Category	Metabolism Diabetes Regulation of Appetite Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	500ug
Host	E.coli
Item no.	CSB-EP017642RA-500
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research Topic	Signal Transduction
Uniprot ID	P28841
Gene Names	Pcsk2
Organism	Rattus norvegicus (Rat)
AA Sequence	GYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGL DLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAY NYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAG EVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDI IEASSISHMPQLIDIYSASWGPTDNGKTVDGPREL TLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNC DGYASSMWTISINSAINDGRTALYDESCSSTLAST FSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPE AAGVFALALEANVDLTWRDMQHLTVLTSKRNQLHD EVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDW KTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNAC EGKENFVRYLEHVQAVITVNATRRGDLNINMTSPM GTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDA RGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPY IDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSI LRKN
Expression Region	109-637aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal 6xHis-tagged
MW	62.3 kDa
Alternative Name(s)	NEC 2 Alternative name(s): KEX2-like endoprotease 2 Prohormone convertase 2 Proprotein convertase 2 Short name: PC2
Relevance	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).
Reference	"Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats."Hakes D.J., Birch N.P., Mezey A., Dixon J.E.Endocrinology 129:3053-3063(1991).
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).
Subcellular Location	Cytoplasmic vesicle, secretory vesicle, Secreted
Protein Families	Peptidase S8 family, Furin subfamily
Tag Information	N-terminal 6xHis-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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