|
Manufacturer |
Cusabio |
|
Category |
|
|
Type |
Proteins |
|
Specific against |
Human |
|
Amount |
10ug |
|
Host |
E.coli |
|
ArtNr |
CSB-EP019049HU-10 |
|
Eclass 6.1 |
34160400 |
|
Eclass 9.0 |
42020190 |
|
Available |
 |
| Research areas |
Immunology |
| Target / Protein |
PTPRC |
| Biologically active |
Not Test |
| Species of origin |
Homo sapiens (Human) |
| Uniprot ID |
P08575 |
| AA Sequence |
QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA STFERENDFSETTTSLSPDNTSTQVSPDSLDNASA FNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGS AANAKLNPTPGSNAISDVPGERSTASTFPTDPVSP LTTTLSLAHHSSAALPARTSNTTITANTSDAYLNA SETTTLSPSGSAVISTTTIATTPSKPTCDEKYANI TVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEV HNLTECKNASVSISHNSCTAPDKTLILDVPPGVEK FQLHDCTQVEKADTTICLKWKNIETFTCDTQNITY RFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNN HKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVI TWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYD LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPH ERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDY TFKAYFHNGDYPGEPFILHHSTSYNSK |
| Tag info |
N-terminal 6xHis-SUMO-tagged |
| Expression Region |
24-575aa |
| Protein length |
Extracellular Domain |
| MW |
76.8 kDa |
| Alternative Name(s) |
Leukocyte common antigen |
| Relevance |
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity |
| Reference |
"Structural variants of human T200 glycoprotein (leukocyte-common antigen)."
Ralph S.J., Thomas M.L., Morton C.C., Trowbridge I.S.
EMBO J. 6:1251-1257(1987) |
| Purity |
Greater than 90% as determined by SDS-PAGE. |
| Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
| Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
