Comparison

Recombinant Human Pregnancy zone protein(PZP),partial

Manufacturer Cusabio
Category
Type Proteins Recombinant
Specific against other
Format Liquid or Lyophilized powder
Amount 200ug
Host E.coli
Item no. CSB-EP019131HU-200
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research areas
Neuroscience
Target / Protein
PZP
Biologically active
Not Test
Expression system
E.coli
Species of origin
Homo sapiens (Human)
Uniprot ID
P20742
AA Sequence
MKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQ GHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLK VFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGV VERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFP ETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFC LSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGE VFTLKATVLNYLPKCIRAEGIEQEKTFSSMTCASG ANVSEQLSLKLPSNVVKESARASFSVLGDILGSAM QNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQ QLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFG
Tag Info
N-terminal 6xHis-tagged
Expression Region
472-821aa
Protein length
Partial of Isoform 2
MW
42.3 kDa
Alternative Name(s)
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Relevance
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
References
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location
Secreted
Protein Families
Protease inhibitor I39 (alpha-2-macroglobulin) family
Tissue Specificity
Plasma. Prominent constituent of late-pregnancy sera.
Tag Information
N-terminal 6xHis-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 200ug
Available: In stock
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