Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
200ug |
Host |
E.coli |
Item no. |
CSB-EP020514HU-200 |
Conjugate/Tag |
GST |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Signal Transduction |
Uniprot ID |
P62070 |
Gene Names |
RRAS2 |
Organism |
Homo sapiens (Human) |
AA Sequence |
AAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQ SYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAG QEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYK FQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEE GQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIR KFQEQECPPSPEPTRKEKDKKGCHC |
Expression Region |
1-204aa |
Sequence Info |
Full Length |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
49.9 kDa |
Alternative Name(s) |
Ras-like protein TC21 Teratocarcinoma oncogene |
Relevance |
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. |
Reference |
"Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line." Drivas G.T., Shih A., Coutavas E., Rush M.G., D'Eustachio P. Mol. Cell. Biol. 10:1793-1798(1990) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. |
Involvement in disease |
Ovarian cancer (OC) |
Subcellular Location |
Cell membrane, Lipid-anchor, Cytoplasmic side |
Protein Families |
Small GTPase superfamily, Ras family |
Tissue Specificity |
Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. |
Paythway |
cAMPsignalingpathway |
Tag Information |
N-terminal GST-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.