Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Amount |
200ug |
Host |
E.coli |
Item no. |
CSB-RP014144h-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Epigenetics and Nuclear Signaling |
Uniprot ID |
Q99471 |
Gene Names |
PFDN5 |
Organism |
Homo sapiens (Human) |
AA Sequence |
AQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQL KVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMY VPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRK IDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQ LTALGAAQATAKA |
Expression Region |
2-154aa |
Sequence Info |
Full Length of Mature Protein |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
44.2 kDa |
Alternative Name(s) |
C-Myc-binding protein Mm-1Myc modulator 1 |
Relevance |
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. |
Reference |
MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.Mori K., Maeda Y., Kitaura H., Taira T., Iguchi-Ariga S.M., Ariga H.J. Biol. Chem. 273:29794-29800(1998) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. |
Subcellular Location |
Isoform 1: Nucleus, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Nucleus |
Protein Families |
Prefoldin subunit alpha family |
Tissue Specificity |
Highly expressed in pancreas and skeletal muscle and moderately in other tissues. |
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