Recombinant Human Heterogeneous nuclear ribonucleoprotein D0(HNRNPD),partial

Manufacturer Cusabio
Category
Type Proteins
Specific against Human
Amount 200ug
Host E.coli
ArtNr CSB-RP025444h-200
Eclass 6.1 34160400
Eclass 9.0 42020190
Available
Research Topic
Transcription
Uniprot ID
Q14103
Gene Names
HNRNPD
Organism
Homo sapiens (Human)
AA Sequence
AVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTA SGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHS EAATAQREEWKMFIGGLSWDTTKKDLKDYFSKFGE VVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQ KEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPD TPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCF ITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQ YQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNY WNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDY SNQQSGYGKVSRRGGHQNSYKPY
Expression Region
18-355aa
Sequence Info
Partial
Tag Info
N-terminal GST-tagged
MW
63.9 kDa
Alternative Name(s)
AU-rich element RNA-binding protein 1
Relevance
Binds with high affinity to RNA molecules that contain AU-rich elents (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Reference
The human HNRPD locus maps to 4q21 and encodes a highly conserved protein.Dempsey L.A., Li M.-J., DePace A., Bray-Ward P., Maizels N.Genomics 49:378-384(1998)
Purity
Greater than 90% as determined by SDS-PAGE.
Storage Buffer
Tris-based buffer, 50% glycerol
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Amount: 200ug
Available: In stock
Listprice: €496.43
Price: €496.43
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